Core problem: The Slayer Seal is Mortal Shell II's easy-mode item. Equipping it permanently disables achievements and trophies on that save file. Unequipping it later does not re-enable them. The game shows multiple confirmation warnings before you can equip it, so accidental activation is hard but not impossible. The developers later explained this was not the original plan (they wanted separate Slayer achievements) but were constrained by the disc version locking achievement definitions early.

1Safe Handling: Pick It Up, Do Not Equip It

Keep it in your inventory. Multiple community posts confirm some later hidden content needs the Slayer Seal present in your inventory even if you never equip it. Grab it, hold it, do not equip it.

2Key Decision: Should You Equip the Slayer Seal?

Want achievements
Never equip it
Play on standard difficulty with other Seals. Community consensus is the game is manageable without the Slayer Seal for most players after early progression. Upgrade weapons, farm Glimpse, learn patterns.
Struggling hard, no achievements
Equip after reading both warnings
Accept the permanent lock on this save. Effects make combat significantly easier and self-sustaining (see below). Save the achievement run for a separate save file.
Already equipped it
Achievements stay disabled on this save
Unequipping does not restore them. Your options are a new save, or on PC only, the community mod workaround (see next section).
Sidearms deal Break damage
Sidearms stagger enemies and break their guard instead of only doing HP damage, opening them up for finishers.
Ripostes restore Health and Resolve
Parry ripostes heal you and refund Resolve, making the loop self-sustaining through long fights.
Slayer Punch (hold charge)
Hold the charge button for an invulnerable dash that deals heavy Break damage and auto-ripostes if it fills the meter.
Net result
Combat becomes significantly easier and self-sustaining. The trade-off is the achievement lock on the save.

3If You Already Equipped It: Your Options

Achievements stay disabled on that save even after unequipping. Community reports and Steam threads are consistent on the permanence. Here is what you can do:

Do not assume unequipping restores achievements. It does not. The lock is tied to the save file's history, not to the Seal's current equipped state. Plan around a new save or the PC mod before spending more time on an achievement run from a Slayer Seal save.

4Common Mistakes to Avoid